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Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme.
Kesari, Pooja; Deshmukh, Anuradha; Pahelkar, Nikhil; Suryawanshi, Abhishek B; Rathore, Ishan; Mishra, Vandana; Dupuis, John H; Xiao, Huogen; Gustchina, Alla; Abendroth, Jan; Labaied, Mehdi; Yada, Rickey Y; Wlodawer, Alexander; Edwards, Thomas E; Lorimer, Donald D; Bhaumik, Prasenjit.
Affiliation
  • Kesari P; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.
  • Deshmukh A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.
  • Pahelkar N; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.
  • Suryawanshi AB; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.
  • Rathore I; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.
  • Mishra V; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.
  • Dupuis JH; Food, Nutrition, and Health Program, Faculty of Land and Food Systems, University of British Columbia, Vancouver, British Columbia, Canada.
  • Xiao H; Summerland Research and Development Center, Agriculture and Agri-Food Canada, Summerland, British Columbia, Canada.
  • Gustchina A; Protein Structure Section, Center for Structural Biology, National Cancer Institute, Frederick, Maryland, USA.
  • Abendroth J; UCB Pharma, Bainbridge Island, Washington, USA.
  • Labaied M; Seattle Structural Genomics Center for Infectious Disease, Seattle, Washington, USA.
  • Yada RY; UCB Pharma, Bainbridge Island, Washington, USA.
  • Wlodawer A; Seattle Structural Genomics Center for Infectious Disease, Seattle, Washington, USA.
  • Edwards TE; Food, Nutrition, and Health Program, Faculty of Land and Food Systems, University of British Columbia, Vancouver, British Columbia, Canada.
  • Lorimer DD; Protein Structure Section, Center for Structural Biology, National Cancer Institute, Frederick, Maryland, USA.
  • Bhaumik P; UCB Pharma, Bainbridge Island, Washington, USA.
Protein Sci ; 31(4): 882-899, 2022 04.
Article in En | MEDLINE | ID: mdl-35048450
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Protozoan Proteins / Aspartic Acid Endopeptidases / Enzyme Precursors Language: En Journal: Protein Sci Journal subject: BIOQUIMICA Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Protozoan Proteins / Aspartic Acid Endopeptidases / Enzyme Precursors Language: En Journal: Protein Sci Journal subject: BIOQUIMICA Year: 2022 Document type: Article Affiliation country: Country of publication: